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Going Global 한스쉘러줄기세포연구센터

Molecular and Cellular Neurobiology Lab.

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  • RESEARCH > Published papers > Prof. Jeong Beom Kim

 

  • Current Research Interests
  • Our lab is interested in understanding the underlying cellular and molecular networks in normal and dysfunctional neurons affecting distinct brain functions. To this end, we are working on two projects: i) investigate local protein synthesis in neurons that underlies spine morphogenesis and synaptic plasticity and ii) identify the cellular and molecular mechanisms of mitochondrial trafficking as well as biogenesis in normal and disease cells.

    Scientists do not yet understand how local protein synthesis regulates dendritic spine morphology, a process that is important for learning and memory. Numerous neurological disorders - including mental retardation - show morphological changes in dendritic spines. Until such understanding is acquired, the molecular link between dysregulation of local protein synthesis and the pathological changes in dendritic spines that lead to mental retardation will remain largely elusive. Our long-term goal is to better understand the fundamental molecular and cellular mechanisms that underlie mental impairment. The objective of immediate goal is to determine the underlying molecular mechanisms of local protein synthesis regulating dendritic spine morphology during neuronal stimulation.

    A current paradigm of mitochondrial transport in axons posits that mitochondrial anterograde movement provides metabolic energy to where it is needed, while retrograde movement allows removal of unhealthy mitochondria. However, the physiological roles of mitochondrial retrograde transport in axons have not been properly addressed due to lack of experimental tools. Such understanding is necessary to identify the molecular link between mitochondrial transport and pathological responses of neurons that lead to neurological disorders. Our long-term goal is to better understand the molecular and cellular mechanisms that underlie mitochondrial dynamics in neurons. The objective of current project is to determine how mitochondrial retrograde transport in axons affects neuronal functions in response to synaptic activity.